STOREDB:STUDY1016 German Thorotrast Study (human data) [DOI:10.20348/STOREDB/1016]

Study meta-data


STUDYIDSTOREDB:STUDY1016
CREATEDON2015-12-10 16:34:05
MODIFIEDON2018-04-18 13:20:34
UPLOADERMandy Birschwilks
DOIDOI:10.20348/STOREDB/1016

Study details


STUDY NAME
German Thorotrast Study (human data)
STUDY STATUS
Restricted: Downloaders have to ask uploader for file access
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Prof G van Kaick
SPECIES
Homo sapiens
SIZE OF COHORT
1000-9999
INTERNAL OR EXTERNAL EXPOSURE
Internal
TYPE OF INTERNAL EXPOSURE
alpha
RADIONUCLIDE
thorium
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
The thorium-based radioactive contrast agent Thorotrast (R) was introduced in 1929 and applied worldwide until the 1950s, especially in angiography and arteriography. Due to the extremely long half-life of several hundred years and the life-long retention
of the thorium dioxide particles in the human body, patients suffer lifetime internal exposure. The health effects from the incorporated thorium were investigated in a few cohort studies with a German study being the largest among them. This retrospective cohort study was set up in 1968 with a follow-up until 2004. The study comprises 2326 Thorotrast patients and 1890 patients of a matched control group. For those being alive at the start of the study in 1968 follow-up was done by clinical examinations on a biannual basis. For the others, causes of death were collected in various ways. Additionally, clinical, radiological
and biophysical studies of patients were conducted and large efforts were made to best estimate the radiation doses
associated with incorporation of the Thorotrast.

The dataset is a MS-Access Database (status 25. Oct. 2010) as given from study PI Prof. v. Kaick, DKFZ Heidelberg, Germany. It includes information on individuals from both the Thorotrast exposed and the control group.

paper: Grosche et al. 2016: The German Thorotrast Cohort Study: a review and how to get access to the data: Radiat Environ Biophys,
DOI 10.1007/s00411-016-0651-8; PMID: 27154786
STOREV2_PROJECTID
http://131.111.32.76/store/project_details.php?projectid=68 (This project has originally been uploaded into the STORE v2 system and is still available here)

STOREDB:DATASET1182 Thorotrast database structure and details [DOI:10.20348/STOREDB/1016/1182]


Created on:2018-10-24 11:39:38 Modified On:2018-10-24 11:40:45
DATASET NAME
Thorotrast database structure and details
DOIDOI:10.20348/STOREDB/1016/1182
DATASET DESCRIPTION
List of table names

STOREDB:DATASET1030 Thorotrast studies patients [DOI:10.20348/STOREDB/1016/1030]


Created on:2015-12-10 16:34:49 Modified On:2015-12-10 16:34:49
DATASET NAME
Thorotrast studies patients
DOIDOI:10.20348/STOREDB/1016/1030
STOREV2_DATASETID
http://131.111.32.76/store/dataset_details.php?datasetid=105 (This dataset has originally been uploaded into the STORE v2 system and is still available here)