| STUDYID | STOREDB:STUDY1016 |
|---|---|
| CREATEDON | 2015-12-10 16:34:05 |
| MODIFIEDON | 2020-09-09 23:31:29 |
| UPLOADER | Mandy Birschwilks |
| DOI | DOI:10.20348/STOREDB/1016 |
| STUDY NAME | ||
|---|---|---|
| German Thorotrast Study (human data) | ||
| STUDY STATUS | ||
| Restricted: Downloaders have to ask uploader for file access | ||
| COUNTRY | ||
| Germany | ||
| PRINCIPAL INVESTIGATOR | ||
| Prof G van Kaick | ||
| SPECIES | ||
| Homo sapiens | ||
| SIZE OF COHORT | ||
| 1000-9999 | ||
| INTERNAL OR EXTERNAL EXPOSURE | ||
| Internal | ||
| TYPE OF INTERNAL EXPOSURE | ||
| alpha | ||
| RADIONUCLIDE | ||
| thorium | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| No | ||
| STUDY DESCRIPTION | ||
| The thorium-based radioactive contrast agent Thorotrast (R) was introduced in 1929 and applied worldwide until the 1950s, especially in angiography and arteriography. Due to the extremely long half-life of several hundred years and the life-long retention
of the thorium dioxide particles in the human body, patients suffer lifetime internal exposure. The health effects from the incorporated thorium were investigated in a few cohort studies with a German study being the largest among them. This retrospective cohort study was set up in 1968 with a follow-up until 2004. The study comprises 2326 Thorotrast patients and 1890 patients of a matched control group. For those being alive at the start of the study in 1968 follow-up was done by clinical examinations on a biannual basis. For the others, causes of death were collected in various ways. Additionally, clinical, radiological and biophysical studies of patients were conducted and large efforts were made to best estimate the radiation doses associated with incorporation of the Thorotrast. The dataset is a MS-Access Database (status 25. Oct. 2010) as given from study PI Prof. v. Kaick, DKFZ Heidelberg, Germany. It includes information on individuals from both the Thorotrast exposed and the control group. paper: Grosche et al. 2016: The German Thorotrast Cohort Study: a review and how to get access to the data: Radiat Environ Biophys, DOI 10.1007/s00411-016-0651-8; PMID: 27154786 | ||
| DATASET NAME | ||
|---|---|---|
| Thorotrast database structure and details | ||
| DOI | DOI:10.20348/STOREDB/1016/1182 | |
| DATASET DESCRIPTION | ||
| List of table names | ||
Type: application/pdf
File size: 195 kilobytes
Uploaded on: 2018-10-24 11:40:09
| DATASET NAME | ||
|---|---|---|
| Thorotrast studies patients | ||
| DOI | DOI:10.20348/STOREDB/1016/1030 | |
Type: application/vnd.ms-access
File size: 43 megabytes
Uploaded on: 2020-09-09 23:29:52
Type: application/pdf
File size: 201 kilobytes
Uploaded on: 2020-09-09 23:12:41
Type: application/pdf
File size: 195 kilobytes
Uploaded on: 2020-09-09 23:12:37
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