STOREDB:STUDY1055 Lung Tumours in Rats After Inhalation of Radon and Treatment with Different Cofactors [DOI:10.20348/STOREDB/1055]

Study meta-data


STUDYIDSTOREDB:STUDY1055
CREATEDON2016-10-18 11:45:46
MODIFIEDON2016-10-18 11:45:46
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1055

Study details


STUDY NAME
Lung Tumours in Rats After Inhalation of Radon and Treatment with Different Cofactors
STUDY STATUS
Published: Open access to everyone
COUNTRY
France
PRINCIPAL INVESTIGATOR
Dr. Michele Morin
SPECIES
Rattus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the risks of lung tumors after inhalation of radon in combination with treatment with various cofactors.

Status: 1973- ongoing; data in ERAD

Treatment: Inhalation of radon (0.1-0.3 μm AMAD 6.2% unattached), treatment with radiation, radionuclides or different cofactors, for details see individual experiments below.

Dosimetry: Activity inhaled (dose from daughter products deposited 2-3 mGy/WLM), for Triton see 02.14

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology unless otherwise stated below

Animal: Male Sprague-Dawley SPF rats of different ages as indicated below

Results: Several pharmaceutical active agents were given together with radon exposure to test whether, on the one hand, certain of these substances (eg cyclophosphamide, bleomycine, methotrexate) would reduce the incidence of cancer, or, on the other hand, whether such substances when used for different therapeutic purposes (eg rifampicine, BCG, isoniazide, endoxan, largactil, phenobarbitol) could act as cofactors for radon-induced cancer. None of the substances had any positive or negative effect on the rate of incidence of radon-induced lung cancer. Alcohol also had no effect whatsoever.

STOREDB:DATASET1093 Link to data and details in ERA [DOI:10.20348/STOREDB/1055/1093]


Created on:2016-10-18 11:46:11 Modified On:2016-10-18 11:46:11
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1055/1093
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=2&StudyId=6