STOREDB:STUDY1082 Liver and Spleen Tumours in Rats After Injection of Th-230 Enriched Thorotrast [DOI:10.20348/STOREDB/1082]

Study meta-data


STUDYIDSTOREDB:STUDY1082
CREATEDON2017-05-03 10:45:10
MODIFIEDON2017-05-03 10:45:10
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1082

Study details


STUDY NAME
Liver and Spleen Tumours in Rats After Injection of Th-230 Enriched Thorotrast
STUDY STATUS
Published: Open access to everyone
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Prof. Wesch
SPECIES
Rattus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast gel-induced tumours, alpha radioactivity in Thorotrast was enriched about 50 times by addition of Th-230.

Status: 1975-1979, terminated

Treatment: Single i.v. injection with different amounts of variously enriched Thorotrast (see below)

Dosimetry: Activity delivered

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology

Animal: Female Wistar rats aged 122 weeks at injection.

Results: The number of animals that developed liver or spleen tumours increased by a factor of 19 in the highest dose-rate groups compared to controls. There was a linear correlation between dose rate and the number of liver and spleen tumours. An increase of the number of injected Thorotrast particles, providing a constant dose rate, had little influence on tumour incidence. However, at a constant relative dose-rate of ten, a fifty-fold increase in the number of particles (12-600 μl) shortened the minimal tumour latency time by about 250 days. The induced liver tumours showed mostly the same morphology as those observed in Thorotrast patients except for a special type of sarcoma which, so far, has not been seen in man and was interpreted as a Kupffer cell sarcoma. No excess lung tumours due to the exhalation of Rn-220 was observed.

STOREDB:DATASET1122 Link to data and details in ERA [DOI:10.20348/STOREDB/1082/1122]


Created on:2017-05-03 10:45:56 Modified On:2017-05-03 10:45:56
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1082/1122
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=4&StudyId=1