STOREDB:STUDY1083 Lung Tumours in Rats After Injection of Normal and Th-228 Enriched Thorotrast and Inhalation of Quartz Dusts [DOI:10.20348/STOREDB/1083]

Study meta-data


STUDYIDSTOREDB:STUDY1083
CREATEDON2017-05-03 10:47:50
MODIFIEDON2017-05-03 10:47:50
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1083

Study details


STUDY NAME
Lung Tumours in Rats After Injection of Normal and Th-228 Enriched Thorotrast and Inhalation of Quartz Dusts
STUDY STATUS
Published: Open access to everyone
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Prof. Wesch
SPECIES
Rattus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine whether thoron exhaled from incorporated Thorotrast whose alpha radioactivity was enriched about 25 times in some groups by an addition of Th-228 would cause lung tumours if combined with inhalation of quartz dust.

Status: 1986-1989, terminated

Treatment: Single i.v. injection of 600 μl enriched Thorotrast (1776 Bq Th-228/ml) followed by inhalation of quartz dust (6 mg/m3 or 30 mg/m 3) over 29 days

Dosimetry: Activity injected

Endpoints: Serial killing (0, 6, 12, and 24 months after exposure) and life-span (spontaneous death) with macroscopic/microscopic pathology

Animal: Female Wistar rats aged 3 0.5 months at injection.

Results: In all quartz-exposed groups, the incidence of lung tumours was greater than 40%, The additional Thorotrast treatment resulted in a marked reduction of tumour latency times and in a higher total incidence (65%) in the animals exposed to the high quartz level (30 mg/m3. Eighty seven of the animals treated with Thorotrast only developed lung tumours. Statistical methods that correct for intercurrent mortality showed a significant increase of the lung tumour risk due to Thorotrast even for the groups receiving the lowest concentration of quartz. The study demonstrates a pronounced interaction between quartz and Thorotrast in lung carcinogenesis.

STOREDB:DATASET1123 Link to data and details in ERA [DOI:10.20348/STOREDB/1083/1123]


Created on:2017-05-03 10:48:18 Modified On:2017-05-03 10:48:18
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1083/1123
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=4&StudyId=2