STOREDB:STUDY1084 Liver Tumours and Diseases in Rats After Fractionated Neutron Exposure or Injection of Non-radioactive Zirconotrast [DOI:10.20348/STOREDB/1084]

Study meta-data


STUDYIDSTOREDB:STUDY1084
CREATEDON2017-05-03 10:49:21
MODIFIEDON2017-05-03 10:49:21
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1084

Study details


STUDY NAME
Liver Tumours and Diseases in Rats After Fractionated Neutron Exposure or Injection of Non-radioactive Zirconotrast
STUDY STATUS
Published: Open access to everyone
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Dr. Spiethoff
SPECIES
Rattus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast induced liver damage. The fractionated neutron exposure was to simulate the radioactive, the Zirkonotrast the chemical damage from Thorotrast.

Status: 1986-1989, terminated

Treatment: Fifty fractions of 0.2 Gy of neutrons (14 MeV neutrons produced by deuterium-tritium reaction, dose rate 0.1 Gy/min) at intervals of 14 days (total 10 Gy) i.v. of 120 μl of Zirkonotrast (Zr-dioxide 13% w/v)

Dosimetry: Activity injected, twin ionisation chamber with tissue equivalent material

Endpoints: Serial killing (6 and 12 months) and life-span (spontaneous death) with macroscopic/microscopic pathology

Animal: Female Wistar rats aged 3-4 months at the start of the irradiation

Results: One year after the beginning of neutron irradiation, the first liver tumours were detected. At the end of the study after almost three years, the incidence of irradiated animals with liver tumours was about 40%. The animals treated additionally with Zirconotrast displayed nearly the same incidence, time of onset and overall number of liver tumours indicating that the fractionated neutron exposure was the exclusive cause of tumour development. Zirconotrast had no tumour promoting or tumour inducing effect. In comparison to earlier animal studies with Thorotrast, the same histological types of benign and malignant liver tumours were found.

STOREDB:DATASET1124 Link to data and details in ERA [DOI:10.20348/STOREDB/1084/1124]


Created on:2017-05-03 10:49:37 Modified On:2017-05-03 10:49:37
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1084/1124
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=4&StudyId=3