STOREDB:STUDY1092 Chernobyl Tissue Bank [DOI:10.20348/STOREDB/1092]

Study meta-data


STUDYIDSTOREDB:STUDY1092
CREATEDON2017-05-19 14:27:29
MODIFIEDON2017-05-19 14:27:29
UPLOADERPaul Schofield
DOIDOI:10.20348/STOREDB/1092

Study details


STUDY NAME
Chernobyl Tissue Bank
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
Other (specify in 'description')
COUNTRY
Ukraine
PRINCIPAL INVESTIGATOR
Prof Gerry Thomas
SPECIES
Homo sapiens
SIZE OF COHORT
1000-9999
OUTCOME
Cancer
EXPOSURE CONTEXT
Environmental
INTERNAL OR EXTERNAL EXPOSURE
Internal
TYPE OF INTERNAL EXPOSURE
mixed
RADIONUCLIDE
multiple
AGE AT EXPOSURE
Childhood
EXPOSURE PATTERN
Transitory
BIOLOGICAL SAMPLE AVAILABLE
Yes
STUDY DESCRIPTION
The Chernobyl Tissue Bank (CTB) was established in 1998 to collect, store and distribute biological samples from patients born on or after 26th April 1967, and resident in the regions of Ukraine and Russia contaminated by fallout from the Chernobyl accident and who developed thyroid cancer. The current collec,on comprises 4500 cases of thyroid cancer and adenoma. 3094 of the 4500 cases are from the exposed areas of Ukraine and Russia, whereas 1406 cases come from the unexposed areas of Ukraine and Russia. There are also 758 post Chernobyl cases (born after 1st December 1986) from Ukraine and Russia: 475 cases are from the exposed areas and a further 283 are from unexposed areas. A thyroid dose is estimated for each case once the pathology consensus diagnosis is agreed. The colletction includes samples from the Ukraine-American cohort.
A sample of blood for extraction of DNA, serum and samples of both frozen (where the tumour is large enough) and formalin fixed paraffin embedded (FFPE) tumour and normal thyroid tissue are provided by each patient. The pathology of every case submitted to the CTB is reviewed by an international panel of pathologists. Molecular biology quality assurance (QA) is carried out on each sample prior to release to researchers. In order to maximise the use of the resource, nucleic acids are ex- tracted from the same frozen tissue block, aliquoted and are distributed to multiple researchers. Individual sections from FFPE blocks from individual cases are also issued to multiple re-searchers. Researchers apply for material through an online portal (https://cisbic.bioinforma,cs.ic.ac.uk/ctb/ html_ctb_public/). Applications are reviewed by an independent external review panel, thus ensuring that the material is used appropriately in first class scientific research. Researchers agree to provide data from their studies back to the project in order that these can be integrated into future studies.
PUBMED ID
24704918

STOREDB:DATASET1132 Chernobyl Tissue Bank [DOI:10.20348/STOREDB/1092/1132]


Created on:2017-05-19 14:28:41 Modified On:2017-05-19 14:28:41
DATASET NAME
Chernobyl Tissue Bank
DOIDOI:10.20348/STOREDB/1092/1132
LINK TO FILE
http://www.chernobyltissuebank.com
DATASET DESCRIPTION
Data available on application from curator.