STOREDB:STUDY1133 German Thorotrast Study (rat data) [DOI:10.20348/STOREDB/1133]

Study meta-data


STUDYIDSTOREDB:STUDY1133
CREATEDON2019-01-25 13:02:21
MODIFIEDON2019-01-28 08:31:58
UPLOADERMandy Birschwilks
DOIDOI:10.20348/STOREDB/1133

Study details


STUDY NAME
German Thorotrast Study (rat data)
STUDY STATUS
Restricted: Downloaders have to ask uploader for file access
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Prof G van Kaick
SPECIES
Rattus norvegicus
OUTCOME
Cancer
EXPOSURE CONTEXT
Medical
INTERNAL OR EXTERNAL EXPOSURE
Internal
TYPE OF INTERNAL EXPOSURE
alpha
RADIONUCLIDE
thorium
BIOLOGICAL SAMPLE AVAILABLE
Yes
STUDY DESCRIPTION
There are data from four different animal studies with Thorotrast from the years 1975 - 1989 in rats.The study tracks key data, study design, number of animals, a list of responsible scientist and some references are already in the ERA database.Institution: Deutsches Krebsforschungszentrum, Heidelberg, Germany.Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast gel-induced tumours, alpha radioactivity in Thorotrast was enriched about 50 times by addition of Th-230.Thorotrast was the brand name of a stabilised colloidal solution of thorium dioxide which was used preferentially as an X-ray contrast medium for arteriography between 1930 and 1950. The administration of the medium led to lifelong chronic alpha-particle irradiation by thorium decay products, mainly in the organs of deposition. Several epidemiological follow-up studies were set up after recognition of these side-effects among which the German study was the largest. MS-Access Database as given from study PI Prof. v. Kaick, DKFZ Heidelberg

FFPE Blocks are stored at HMGU.

STOREDB:DATASET1200 List of references [DOI:10.20348/STOREDB/1133/1200]


Created on:2019-01-25 13:17:15 Modified On:2019-01-28 08:34:22
DATASET NAME
List of references
DOIDOI:10.20348/STOREDB/1133/1200
DATASET DESCRIPTION
This list provides more than 200 references.References are available in electronic form (pdf).If you are interested, please send an e-mail to store[at]bfs.de and stating the file name. Example------You wish the PDF of the following reference------"van Kaick G, Dalheimer A, Hornik S, Kaul A, Liebermann D, Lührs H, Spiethoff A, Wegener K, Wesch H.__The German thorotrast study: recent results and assessment of risks.Radiat.Res. 152(6 Suppl):S64-S71; 1999"------ 1999_RadiatRes_V152_S64_vanKaick.pdf <-- this is the file name

STOREDB:DATASET1199 Thorotrast Studies Animals [DOI:10.20348/STOREDB/1133/1199]


Created on:2019-01-25 13:04:56 Modified On:2019-01-28 08:38:38
DATASET NAME
Thorotrast Studies Animals
DOIDOI:10.20348/STOREDB/1133/1199
DATASET DESCRIPTION
There are data from four different animal studies with Thorotrast from the years 1975 - 1989 in rats.The study tracks key data, study design, number of animals, list of responsible scientist and some references are already in the ERA database.
Institution: Deutsches Krebsforschungszentrum, Heidelberg, Germany
Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast gel-induced tumours, alpha radioactivity in Thorotrast was enriched about 50 times by addition of Th-230.

04.01
Liver and Spleen Tumours in Rats After Injection of Th-230 Enriched Thorotrast
04.02
Lung Tumors in Rats After Injection of Normal and Th-228 Enriched Thorotrast and Inhalation of Quartz Dusts
04.03
Liver Tumors and Diseases in Rats After Fractionated Neutron Exposure or Injection of Nonradioactive Zirconotrast
04.04
Liver and Spleen Tumors in Rats After Injection of Zirconotrast to Which Different Amounts of Th-228/Th-230 Were Added