STOREDB:STUDY1014 Comparative Toxicity and Retention of Am-241, Pu-239, and U-233 in Mice [DOI:10.20348/STOREDB/1014]

Study meta-data


STUDYIDSTOREDB:STUDY1014
CREATEDON2015-12-10 16:16:02
MODIFIEDON2015-12-10 16:16:02
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1014

Study details


STUDY NAME
Comparative Toxicity and Retention of Am-241, Pu-239, and U-233 in Mice
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
CC-Attribution Non-Commercial Share Alike
COUNTRY
United Kingdom
PRINCIPAL INVESTIGATOR
Dr Michele Ellender
SPECIES
Mus musculus
BIOLOGICAL SAMPLE AVAILABLE
Yes
STUDY DESCRIPTION
Aim: To determine the long-term risks from contamination by different alpha emitters Treatment: Nine i.p. injections of Am-241 citrate, Pu-239 citrate or U-233 citrate (the activity was given as 9 injections over a short period to avoid any toxic effects due to the chemical toxicity of uranium; all groups were treated similarly)Dosimetry: Activities calculated to give the same average bone dose at 500 days at each group on the basis of data on distribution and retention (serial killing 1, 7, 14, 28, 112, 224,448 days) Endpoints: Life-span study with macroscopic/microscopic pathologyAnimal: Male CBA/H mice aged 12 weeksResults: Statistical modelling by Cox regression showed that, considering all three nuclides together, there was a highly significant increase in hazard of death from osteosarcoma or myeloid leukaemia with increasing dose rate. For osteosarcoma, the effect was significantly greater for 239Pu than for241Am. The analysis for233U was statistically consistent with no effect of dose rate. For example, the increase in relative hazard of death from osteosarcoma for an increase in dose rate of 1 mGy/d was 4.2 (2.7 - 6.5) for239Pu, 2.3 (1.4 - 3.4) for241Am and 1.1 (0.4 - 3.1) for233U. For myeloid leukaemia there was no significant difference between 239Pu and 241Am in the effect of dose rate. The increase in relative hazard from myeloid leukaemia for an increase in dose rate of 1 mGy/d was 1.8 (1.1 - 2.8) for239Pu, 2.0 (1.4 - 2.9) for241Am and 1.5 (0.8 - 2.7) for233U. Significant increases in hepatic (241Am) and renal (233U) carcinoma were also recorded.Studies of the distribution of the nuclides within the skeleton showed differences in their retention in individual bones and within bone. The proportions of I-decays occurring near to bone surfaces and in bone marrow were in the order: 239Pu > 241Am > 233U, For osteosarcoma, the relative effectiveness of the nuclides was consistent with the proportion of dose delivered near to endosteal surfaces. For myeloid leukaemia, the greater effectiveness of 239Pu and 241Am compared to 233U was consistent with their accumulation in the marrow.
https://era.bfs.de/studies_description_from_db.php?LabId=8
STOREV2_PROJECTID
http://131.111.32.76/store/project_details.php?projectid=11 (This project has originally been uploaded into the STORE v2 system and is still available here)

STOREDB:DATASET1028 Zoomable histopathology images [DOI:10.20348/STOREDB/1014/1028]


Created on:2015-12-10 16:20:54 Modified On:2015-12-10 16:20:54
DATASET NAME
Zoomable histopathology images
DOIDOI:10.20348/STOREDB/1014/1028
LINK TO FILE
http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2324
DATASET DESCRIPTION
Mouse number M1305
Control. Hemangiosarcoma, knee

STOREDB:DATASET1027 Zoomable histopathology images [DOI:10.20348/STOREDB/1014/1027]


Created on:2015-12-10 16:20:12 Modified On:2015-12-10 16:20:12
DATASET NAME
Zoomable histopathology images
DOIDOI:10.20348/STOREDB/1014/1027
LINK TO FILE
http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2322
DATASET DESCRIPTION
Mouse number M1275
Control. Gut intusseption

STOREDB:DATASET1026 Zoomable histopathology images [DOI:10.20348/STOREDB/1014/1026]


Created on:2015-12-10 16:19:34 Modified On:2015-12-10 16:19:34
DATASET NAME
Zoomable histopathology images
DOIDOI:10.20348/STOREDB/1014/1026
LINK TO FILE
http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2321
DATASET DESCRIPTION
Mouse number M1265
Control. Odontoma. Jaw

STOREDB:DATASET1025 Zoomable histopathology images [DOI:10.20348/STOREDB/1014/1025]


Created on:2015-12-10 16:18:57 Modified On:2015-12-10 16:18:57
DATASET NAME
Zoomable histopathology images
DOIDOI:10.20348/STOREDB/1014/1025
LINK TO FILE
http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2320
DATASET DESCRIPTION
Mouse number M1262
Control. Hemangiosarcoma, lumbar vertebrae

STOREDB:DATASET1024 Zoomable histopathology images [DOI:10.20348/STOREDB/1014/1024]


Created on:2015-12-10 16:18:01 Modified On:2015-12-10 16:18:01
DATASET NAME
Zoomable histopathology images
DOIDOI:10.20348/STOREDB/1014/1024
LINK TO FILE
http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2325
DATASET DESCRIPTION
Mouse number 1503
Low dose Americium. Carcinoma NOS. salivary gland.

STOREDB:DATASET1023 Publications from Project [DOI:10.20348/STOREDB/1014/1023]


Created on:2015-12-10 16:16:49 Modified On:2015-12-10 16:16:49
DATASET NAME
Publications from Project
DOIDOI:10.20348/STOREDB/1014/1023
DATASET DESCRIPTION
List of publications arising from the project
STOREV2_DATASETID
http://131.111.32.76/store/dataset_details.php?datasetid=11 (This dataset has originally been uploaded into the STORE v2 system and is still available here)