STOREDB:STUDY1043 Life-span Study of the Induction of Lung Tumours in CBA/Ca Mice by Pu-239 Dioxide [DOI:10.20348/STOREDB/1043]
|Life-span Study of the Induction of Lung Tumours in CBA/Ca Mice by Pu-239 Dioxide|
|Published: Open access to everyone|
|Dr. Nick Priest|
|BIOLOGICAL SAMPLE AVAILABLE|
|Purpose: To investigate the processes preceding and accompanying Pu-induction of lung tumours in mice and to compare histological and site characteristics of mouse tumours with those in man with a view of evaluating the validity of the mouse lung tumour model.
Status: 1990 - 1993
Treatment: Inhalation Pu-239 dioxide (AMAD 1.5 μm) to give a mean IAD of about 100 Bq (corresponding to the maximal lung tumour incidence). Serial sacrifices of 50 Pu-exposed and 50 sham-exposed mice (including intercurrent deaths) at 8, 12, 16, 20, 24, and 28 months. Remainder killed when moribund. Groups of 4 Pu-exposed mice killed for the assessment of residual Pu in lung.
Dosimetry: Cumulative calculated dose to lung at 24 months is 4.5 Gy.
Endpoints: Macroscopic/microscopic pathology of the lung, and all macroscopically obvious abnormalities.
Animal: Female CBA/Ca mice aged 63 ± 5 days.
Results: Spontaneous incidence of lung tumours in control mice was below 10% up to an age of 20 months and increased with age after this time. Pu-239 exposed mice showed a significant and progressive increase in lung tumour incidence with the difference between control and exposed mice increasing with age. The lung tumours observed in exposed mice were mostly of the bronchiolo-alveolar type; no small cell tumours and, in contrast to rats, no squamous tumours were seen. Studies carried out in parallel in the same strain followed the long-term behaviour of Pu-239 and U-235 dioxide particles in lung.
References: Morgan A., P.N. Brooks, T.M. Eldred and K.A. Ambrose. Lifespan study of tumour induction in CBA mice following inhalation exposure to 239Pu O2. In: Poster at 24th ESRB Meeting; Erfurt., 1992.
Kellington R.P., T.M. Eldred, K. Ambrose and P.N. Brooks. Lifespan study of CBA mice exposed to 239PuO2 by inhalation., 1995. In press
STOREDB:DATASET1077 Link to data and details in ERA [DOI:10.20348/STOREDB/1043/1077]
Created on:2016-09-12 13:04:15 Modified On:2016-09-29 18:11:13
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