STOREDB:STUDY1044 Effects of Alpha and Beta Emitters in Lung [DOI:10.20348/STOREDB/1044]

Study meta-data


STUDYIDSTOREDB:STUDY1044
CREATEDON2016-09-29 18:07:55
MODIFIEDON2016-09-29 18:07:55
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1044

Study details


STUDY NAME
Effects of Alpha and Beta Emitters in Lung
STUDY STATUS
Published: Open access to everyone
COUNTRY
United Kingdom
PRINCIPAL INVESTIGATOR
Dr. Jeremy Kellington
SPECIES
Mus musculus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the relative biological effectiveness (RBE) of inhaled, insoluble alpha- and beta-emitting radionuclides with respect to late carcinogenic effects.

Status: 1990 - 1994

Treatment: Single nose-only exposure to fused aluminosilicate particles (FAP) labelled with Cm-242 (alpha-emitter) or Ca-45 (beta-emitter), AMAD about 1,6 μm, 1.2-1.3 sigma g.

Dosimetry: Initial alveolar deposit (IAD and radiochemical analysis to determine Cm-242 or Ca-45 content of lungs from mice killed at 1, 7, 28, 84, 196, 308, 504, and 672 days post exposure. Trapezoidal method used to calculate average radiation dose to lungs.

Endpoints: Life-span study with sacrifice of moribund animals. Necropsy observation and histopathology of all macroscopically obvious abnormalities. Lungs cleared to determine the absolute number of lung lesions.

Animal: Female CBA/Ca mice 10 weeks of age at time of exposure

Results: The survival studies do not indicate differences between the treated and non-treated groups. Macroscopic studies on the lung suggest, however, that lung tumours in controls begin to appear at an age of about 700 days and increase steadily to about 30% towards the end of the life. Following exposure to Cm-242 or Ca-45 labelled FAPs the latency period appeared reduced and the incidence increased. There was, as yet, no indication that the RBE could be 20 for alpha particles. The histopathological evaluation is now under way to confirm the these data.

STOREDB:DATASET1078 Link to data and details in ERA [DOI:10.20348/STOREDB/1044/1078]


Created on:2016-09-29 18:08:23 Modified On:2016-09-29 18:08:23
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1044/1078
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=1&StudyId=3