STOREDB:STUDY1051 Lung Tumours in Rats After Inhalation of Radon and Mine Polluants or Tobacco [DOI:10.20348/STOREDB/1051]

Study meta-data


STUDYIDSTOREDB:STUDY1051
CREATEDON2016-10-06 19:01:14
MODIFIEDON2016-10-06 19:01:14
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1051

Study details


STUDY NAME
Lung Tumours in Rats After Inhalation of Radon and Mine Polluants or Tobacco
STUDY STATUS
Published: Open access to everyone
COUNTRY
France
PRINCIPAL INVESTIGATOR
Dr. Michele Morin
SPECIES
Rattus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the risks of lung tumors after radon inhalation together with tobacco, soot or gases

Status: 1972 - 1982, terminated; data in ERAD except for groups indicated in red

Treatment: Inhalation of radon (0.1-0.3 μm AMAD 6.2% unattached), inhalation of tobacco smoke usually 2-3 h for 5 days per week. For further details see individual experiments below.

Dosimetry: Activity inhaled (dose from daughter products deposited 2-3 mGy/WLM)

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology unless otherwise stated below

Animal: Male Sprague-Dawley SPF rats of different ages as indicated in the tables, controls see under 02.01

Results: Several pollutants occurring in mines were tested with respect to their capacity to act in synergism with radon. No synergism was found between radon and uranium mineral or between radon and diesel exhaust fumes. Rats given intra-tracheal (IT) soot from engines used in mines together with radon had a two times greater lung cancer rate than those exposed only to radon or to radon and IT saline solution. No synergism was seen between radon and sulfur dioxide (experiment 1976). On the contrary, a clear synergism could be demonstrated for tobacco fumes. An experiment in 1975 with rats exposed to 1800 WL of radon alone or together with 350 hours of passive smoking yielded twice the lung cancer rate in the rats exposed additionally to smoking. A study of the influence of timing between radon exposure and smoking in 50 rats exposed to 1600 WLM of radon (in 1979) showed that radon alone produced 18% lung cancers, smoking prior radon exposure produced 16% cancers and radon followed by smoking produced as many as 80%.

STOREDB:DATASET1085 Link to data and details in ERA [DOI:10.20348/STOREDB/1051/1085]


Created on:2016-10-06 19:01:30 Modified On:2016-10-06 19:01:30
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1051/1085
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=2&StudyId=3