STOREDB:STUDY1076 Ovarian tumours in mice after X-ray and neutron exposure [DOI:10.20348/STOREDB/1076]

Study meta-data


STUDYIDSTOREDB:STUDY1076
CREATEDON2017-04-25 10:32:15
MODIFIEDON2017-04-25 10:32:15
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1076

Study details


STUDY NAME
Ovarian tumours in mice after X-ray and neutron exposure
STUDY STATUS
Published: Open access to everyone
COUNTRY
Italy
PRINCIPAL INVESTIGATOR
Dr Covelli
SPECIES
Mus musculus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the dose relationship and RBE for ovarian murine tumors after X-ray and neutron exposure.

Status: 1982 - 1987, terminated, data in ERAD

Treatment: Single acute exposure to 250 kVp X-rays (1.5 mm HVL, 60 mGy/min) or 1.5 MeV neutrons from a van de Graaff accelerator at the JRC Ispra (1.83 mGy/min)

Dosimetry: Twin ionization chamber method, ENDIP

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology

Animal: Female (C57Bl/Cne x C3H/Cne)F1 (BC3F1) mice aged 3 months

Results: A significant increase in life-shortening was observed for single neutron exposure to 0.08 Gy. or more. Assuming a linear non-threshold dose-effect relationship, the RBE value is 12.3 for 1.5 MeV neutrons. A statistically significant increase in solid tumors is seen for single neutron exposure from 0.08 Gy and for X-ray exposure from 1 Gy. The data for neutrons at low doses can be fitted to a linear dose effect relationship. A separate analysis of of ovarian tumor induction substantiates the hypothesis of a threshold for X-rays, whereas such a threshold is not evident for neutrons. A trend analysis confirms these findings. When death rates are analyzed, a general agreement between their shift to earlier times and tumor induction was found.

STOREDB:DATASET1116 Link to data and details in ERA [DOI:10.20348/STOREDB/1076/1116]


Created on:2017-04-25 10:32:37 Modified On:2017-04-25 10:32:37
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1076/1116
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=3&StudyId=1