| STUDYID | STOREDB:STUDY1076 |
|---|---|
| CREATEDON | 2017-04-25 10:32:15 |
| MODIFIEDON | 2017-04-25 10:32:15 |
| UPLOADER | Michael Gruenberger |
| DOI | DOI:10.20348/STOREDB/1076 |
| STUDY NAME | ||
|---|---|---|
| Ovarian tumours in mice after X-ray and neutron exposure | ||
| STUDY STATUS | ||
| Published: Open access to everyone | ||
| COUNTRY | ||
| Italy | ||
| PRINCIPAL INVESTIGATOR | ||
| Dr Covelli | ||
| SPECIES | ||
| Mus musculus | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| No | ||
| STUDY DESCRIPTION | ||
| Purpose: To determine the dose relationship and RBE for ovarian murine tumors after X-ray and neutron exposure.
Status: 1982 - 1987, terminated, data in ERAD Treatment: Single acute exposure to 250 kVp X-rays (1.5 mm HVL, 60 mGy/min) or 1.5 MeV neutrons from a van de Graaff accelerator at the JRC Ispra (1.83 mGy/min) Dosimetry: Twin ionization chamber method, ENDIP Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Female (C57Bl/Cne x C3H/Cne)F1 (BC3F1) mice aged 3 months Results: A significant increase in life-shortening was observed for single neutron exposure to 0.08 Gy. or more. Assuming a linear non-threshold dose-effect relationship, the RBE value is 12.3 for 1.5 MeV neutrons. A statistically significant increase in solid tumors is seen for single neutron exposure from 0.08 Gy and for X-ray exposure from 1 Gy. The data for neutrons at low doses can be fitted to a linear dose effect relationship. A separate analysis of of ovarian tumor induction substantiates the hypothesis of a threshold for X-rays, whereas such a threshold is not evident for neutrons. A trend analysis confirms these findings. When death rates are analyzed, a general agreement between their shift to earlier times and tumor induction was found. | ||
| DATASET NAME | ||
|---|---|---|
| Link to data and details in ERA | ||
| DOI | DOI:10.20348/STOREDB/1076/1116 | |
| LINK TO FILE | ||
| https://era.bfs.de/studies_details.php?LabId=3&StudyId=1 | ||