STOREDB:STUDY1080 Tumours and survival in mice in dependence of age after X-ray and neutron exposure [DOI:10.20348/STOREDB/1080]

Study meta-data


STUDYIDSTOREDB:STUDY1080
CREATEDON2017-04-25 10:37:16
MODIFIEDON2017-04-25 10:37:16
UPLOADERMichael Gruenberger
DOIDOI:10.20348/STOREDB/1080

Study details


STUDY NAME
Tumours and survival in mice in dependence of age after X-ray and neutron exposure
STUDY STATUS
Published: Open access to everyone
COUNTRY
Italy
PRINCIPAL INVESTIGATOR
Dr Covelli
SPECIES
Mus musculus
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Purpose: To determine the RBE in function of the age of the animal.

Status: 1984 - 1989, terminated

Scientists: V. Di Majo; M. Coppola; S. Rebessi; V. Covelli;

Treatment: Single exposure to 250 kVp X-rays (133 mGy/min, 1.5 mm HVL) or fission neutrons (4 mGy/min, 0.4 MeV) from the biological facility of the RSV-TAPIRO reactor at Casaccia

Dosimetry: Twin ionization chamber method, ENDIP

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology

Animal: (C57Bl/Cne x C3H/Cne)F1 (BC3F1) male mice aged 17.5 days post conception, 3 and 19 months

Results: Liver tumors increase slightly in mice irradiated prior birth after X-ray doses of 0.3 to 2.1 of X-rays and more markedly after neutron doses of 0.09 to 0.62 Gy. At an age of 3 months, incidence is higher after 2 Gy of X-rays or 0.17 Gy of neutrons. At an age of 19 months, very few liver tumors could be induced by either type of radiation. The data from X-rays indicated a quadratic relationship, those from neutrons a linear one. The RBE for neutrons was 28 at a dose of 0.09 and 131 at a dose of 0.17 for irradiation at 3 months. On the other hand, prenatal irradiation or irradiation at an age of 19 months did not cause life-shortening although it increased the rate of solid tumors and reticulosarcoma. At an age of 3 month life-shortening associated with increased tumor incidence was noticeable. The RBE was ranged between 3 and 18 with the higher levels at the lower doses.

STOREDB:DATASET1120 Link to data and details in ERA [DOI:10.20348/STOREDB/1080/1120]


Created on:2017-04-25 10:37:38 Modified On:2017-04-25 10:37:38
DATASET NAME
Link to data and details in ERA
DOIDOI:10.20348/STOREDB/1080/1120
LINK TO FILE
https://era.bfs.de/studies_details.php?LabId=3&StudyId=5