STOREDB:STUDY1080 Tumours and survival in mice in dependence of age after X-ray and neutron exposure [DOI:10.20348/STOREDB/1080]
|Tumours and survival in mice in dependence of age after X-ray and neutron exposure|
|Published: Open access to everyone|
|BIOLOGICAL SAMPLE AVAILABLE|
|Purpose: To determine the RBE in function of the age of the animal.
Status: 1984 - 1989, terminated
Scientists: V. Di Majo; M. Coppola; S. Rebessi; V. Covelli;
Treatment: Single exposure to 250 kVp X-rays (133 mGy/min, 1.5 mm HVL) or fission neutrons (4 mGy/min, 0.4 MeV) from the biological facility of the RSV-TAPIRO reactor at Casaccia
Dosimetry: Twin ionization chamber method, ENDIP
Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology
Animal: (C57Bl/Cne x C3H/Cne)F1 (BC3F1) male mice aged 17.5 days post conception, 3 and 19 months
Results: Liver tumors increase slightly in mice irradiated prior birth after X-ray doses of 0.3 to 2.1 of X-rays and more markedly after neutron doses of 0.09 to 0.62 Gy. At an age of 3 months, incidence is higher after 2 Gy of X-rays or 0.17 Gy of neutrons. At an age of 19 months, very few liver tumors could be induced by either type of radiation. The data from X-rays indicated a quadratic relationship, those from neutrons a linear one. The RBE for neutrons was 28 at a dose of 0.09 and 131 at a dose of 0.17 for irradiation at 3 months. On the other hand, prenatal irradiation or irradiation at an age of 19 months did not cause life-shortening although it increased the rate of solid tumors and reticulosarcoma. At an age of 3 month life-shortening associated with increased tumor incidence was noticeable. The RBE was ranged between 3 and 18 with the higher levels at the lower doses.
STOREDB:DATASET1120 Link to data and details in ERA [DOI:10.20348/STOREDB/1080/1120]
Created on:2017-04-25 10:37:38 Modified On:2017-04-25 10:37:38
|Link to data and details in ERA|
|LINK TO FILE|