STOREDB:STUDY1100 The role of PPAR alpha in radiation induced heart disease [DOI:10.20348/STOREDB/1100]

Study meta-data


STUDYIDSTOREDB:STUDY1100
CREATEDON2017-11-20 16:43:31
MODIFIEDON2017-11-23 13:54:20
UPLOADERVikram Subramanian
DOIDOI:10.20348/STOREDB/1100

Study details


STUDY NAME
The role of PPAR alpha in radiation induced heart disease
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
CC-Attribution Non-Commercial Share Alike
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Dr. Micheal J. Atkinson, Dr.Soile Tapio, Dr.Omid Azimzadeh
SPECIES
Mus musculus
SIZE OF COHORT
0-999
OUTCOME
Cardiovascular
EXPOSURE CONTEXT
Medical
INTERNAL OR EXTERNAL EXPOSURE
External
TYPE OF EXTERNAL EXPOSURE
X-ray
TYPE OF INTERNAL EXPOSURE
X-ray
AGE AT EXPOSURE
Adult
EXPOSURE PATTERN
Acute
DOSE RATE
High
BIOLOGICAL SAMPLE AVAILABLE
Yes
STUDY DESCRIPTION
The PPAR alpha, important regulator of fatty acid metabolism in heart shown to be involved in development of cardiovascular disease. The radiation induced impairment of fatty acid metabolism was observed due to increased phosphorylation of PPAR alpha that leads to reduction in the expression of key proteins involved in fatty acid oxidation and transport with 16 Gy irradiation after 16 weeks and 40 weeks in C57BL/6J mice. The aim of our present study is to examine the influence of PPAR-α in the development of different cardiovascular disease phenotype after high dose local ionizing radiation in heart after long term exposure compared to wild type mice and the role of PPAR-α in this disease process. Male mice strain (C57BL/6J) with different genotype for PPAR-α; PPAR-α wild type, PPAR-α +/- (Heterozygous mutant), PPAR-α -/- (Homozygous mutant), were irradiated locally on the heart with single X-ray doses of 8 and 16 Gy at the age of 8 weeks. Radiation induced effects on heart from different PPAR-α genotypes were analyzed by quantitative proteomics after 20 weeks of exposure. Further proteomics data were validated using bioinformatics tools, western blotting, immunohistochemistry, election microscopy, and ELISA.
MEAN DURATION OF FOLLOW-UP (WEEKS)
20

STOREDB:DATASET1151 The role of ppar alpha in radiation- induced heart disease [DOI:10.20348/STOREDB/1100/1151]


Created on:2017-11-21 10:49:33 Modified On:2017-11-21 10:49:33
DATASET NAME
The role of ppar alpha in radiation- induced heart disease
DOIDOI:10.20348/STOREDB/1100/1151
DATASET DESCRIPTION
Mass spectrometry raw files

STOREDB:DATASET1150 The role of ppar alpha in radiation-induced heart disease [DOI:10.20348/STOREDB/1100/1150]


Created on:2017-11-21 10:27:15 Modified On:2017-11-21 10:48:32
DATASET NAME
The role of ppar alpha in radiation-induced heart disease
DOIDOI:10.20348/STOREDB/1100/1150
DATASET DESCRIPTION
Mass spectrometry raw files
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SUV9284A53MA3 053-M 16Gy 3

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SUV9284A47MA3 047-M 8Gy 3

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SUV9284A46MA3 046-M 8Gy 2

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SUV9284A45MA3 045-M 8Gy 1

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SUV9284A43MA3 043-M 0Gy 5

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SUV9284A42MA3 042-M 0Gy 4

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SUV9284A41MA3 041-M 0Gy 3

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SUV9284A40MA3 040-M 0Gy 2

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SUV9284A39MA3 039-M 0Gy 1

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SUV9284A37MA3 037-H 16Gy 5

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SUV9284A36MA3 036-H 16Gy 4

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SUV9284A35MA3 035-H 16Gy 3

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SUV9284A34MA3 034-H 16Gy 2

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SUV9284A33MA4 033-H 16Gy 1

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SUV9284A23MA3 023-H 0Gy 4

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SUV9284A49MA3 049-M 8Gy 5

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SUV9284A48MA3 048-M 8Gy 4

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SUV9284A47MA3 047-M 8Gy 3

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SUV9284A46MA3 046-M 8Gy 2

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SUV9284A45MA3 045-M 8Gy 1

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SUV9284A24MA3 024-H 0Gy 5

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SUV9284A23MA3 023-H 0Gy 4

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SUV9284A22MA3 022-H 0Gy 3

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SUV9284A21MA3 021-H 0Gy 2

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SUV9284A15MA3 015-W 16Gy 2

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SUV9284A14MA3 014-W 16Gy 1

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SUV9284A12MA3 012-W 8Gy 5

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SUV9284A11MA3 011-W 8Gy 4

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SUV9284A10MA4 010-W 8Gy 3

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SUV9284A9MA3__009-W_8Gy_2

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SUV9284A8MA3__008-W_8Gy_1

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SUV9284A5MA3__005-W_0Gy_4

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SUV9284A4MA3__004-W_0Gy_3

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SUV9284A3MA3__003-W_0Gy_2

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SUV9284A2MA3__002-W_0Gy_1

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SUV9284A6MA3__006-W_0Gy_5

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SUV9284A55MA3 055-M 16Gy 5

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SUV9284A52MA3 052-M 16Gy 2

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SUV9284A51MA3 051-M 16Gy 1

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SUV9284A49MA3 049-M 8Gy 5

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SUV9284A31MA3 031-H 8Gy 4

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SUV9284A30MA3 030-H 8Gy 3

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SUV9284A29MA3 029-H 8Gy 2

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SUV9284A28MA3 028-H 8Gy 1

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SUV9284A25MA3 025-H 0Gy 6

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SUV9284A20MA3 020-H 0Gy 1

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SUV9284A18MA3 018-W 16Gy 5

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SUV9284A17MA3 017-W 16Gy 4

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SUV9284A16MA3 016-W 16Gy 3

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