STUDYID | STOREDB:STUDY1107 |
---|---|
CREATEDON | 2018-07-20 11:34:00 |
MODIFIEDON | 2018-07-20 14:52:42 |
UPLOADER | Daniela Hladik |
DOI | DOI:10.20348/STOREDB/1107 |
STUDY NAME | ||
---|---|---|
DNA damage accumulation during fractionated low-dose radiation compromises hippocampal neurogenesis | ||
STUDY STATUS | ||
Published: Open access to everyone | ||
COUNTRY | ||
Germany | ||
SPECIES | ||
Mus musculus | ||
SIZE OF COHORT | ||
0-999 | ||
OUTCOME | ||
Cognitive effects | ||
EXPOSURE CONTEXT | ||
Medical | ||
INTERNAL OR EXTERNAL EXPOSURE | ||
External | ||
TYPE OF EXTERNAL EXPOSURE | ||
gamma | ||
AGE AT EXPOSURE | ||
Juvenile | ||
EXPOSURE PATTERN | ||
Acute | ||
DOSE RATE | ||
High | ||
BIOLOGICAL SAMPLE AVAILABLE | ||
No | ||
STUDY DESCRIPTION | ||
Genetically-defined mouse strains varying in their DNA repair capacity were exposed to LDR (5x/10x/15x/20x 0.1Gy) and hippocampal dentate gyri from juvenile and adult mice were analyzed 72h, 1, 3 and 6 months after final exposure. To examine the impact of LDR on neurogenesis, persistent DNA damage was assessed by quantifying 53BP1-foci in hippocampal neurons. Moreover, subpopulations of neuronal stem/progenitor cells were quantified and dendritic arborisation of developing neurons were assessed. To unravel molecular mechanism involved in radiation-induced neurotoxicity, signaling networks were analyzed by proteome analysis. | ||
MEAN DURATION OF FOLLOW-UP (WEEKS) | ||
24 |
DATASET NAME | ||
---|---|---|
Proteinlist_filtered_2 Unique Peptides | ||
DOI | DOI:10.20348/STOREDB/1107/1159 |
Type: application/vnd.ms-excel
File size: 550 kilobytes
Uploaded on: 2018-07-20 11:49:18