STOREDB:STUDY1107 DNA damage accumulation during fractionated low-dose radiation compromises hippocampal neurogenesis [DOI:10.20348/STOREDB/1107]

Study meta-data


STUDYIDSTOREDB:STUDY1107
CREATEDON2018-07-20 11:34:00
MODIFIEDON2018-07-20 14:52:42
UPLOADERDaniela Hladik
DOIDOI:10.20348/STOREDB/1107

Study details


STUDY NAME
DNA damage accumulation during fractionated low-dose radiation compromises hippocampal neurogenesis
STUDY STATUS
Published: Open access to everyone
COUNTRY
Germany
SPECIES
Mus musculus
SIZE OF COHORT
0-999
OUTCOME
Cognitive effects
EXPOSURE CONTEXT
Medical
INTERNAL OR EXTERNAL EXPOSURE
External
TYPE OF EXTERNAL EXPOSURE
gamma
AGE AT EXPOSURE
Juvenile
EXPOSURE PATTERN
Acute
DOSE RATE
High
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Genetically-defined mouse strains varying in their DNA repair capacity were exposed to LDR (5x/10x/15x/20x 0.1Gy) and hippocampal dentate gyri from juvenile and adult mice were analyzed 72h, 1, 3 and 6 months after final exposure. To examine the impact of LDR on neurogenesis, persistent DNA damage was assessed by quantifying 53BP1-foci in hippocampal neurons. Moreover, subpopulations of neuronal stem/progenitor cells were quantified and dendritic arborisation of developing neurons were assessed. To unravel molecular mechanism involved in radiation-induced neurotoxicity, signaling networks were analyzed by proteome analysis.
MEAN DURATION OF FOLLOW-UP (WEEKS)
24

STOREDB:DATASET1159 Proteinlist_filtered_2 Unique Peptides [DOI:10.20348/STOREDB/1107/1159]


Created on:2018-07-20 11:36:14 Modified On:2018-07-20 11:36:14
DATASET NAME
Proteinlist_filtered_2 Unique Peptides
DOIDOI:10.20348/STOREDB/1107/1159