STOREDB:STUDY1108 Thyroid diseases near Semipalatinsk Nuclear Test Site - Description [DOI:10.20348/STOREDB/1108]

Study meta-data


STUDYIDSTOREDB:STUDY1108
CREATEDON2018-08-11 22:06:38
MODIFIEDON2018-08-11 22:22:21
UPLOADERBernd Grosche
DOIDOI:10.20348/STOREDB/1108

Study details


STUDY NAME
Thyroid diseases near Semipalatinsk Nuclear Test Site - Description
STUDY STATUS
Published: Open access to everyone
COUNTRY
Kazakhstan
PRINCIPAL INVESTIGATOR
Nobuo Takeichi, Yoshihiro Noso, Kazbek N. Apsalikov
SPECIES
Homo sapiens
SIZE OF COHORT
1000-9999
MELODI RESEARCH PRIORITY
Other activities contributing to low-dose risk research
EXPOSURE CONTEXT
Environmental
INTERNAL OR EXTERNAL EXPOSURE
External
TYPE OF EXTERNAL EXPOSURE
gamma
TYPE OF INTERNAL EXPOSURE
mixed
BIOLOGICAL SAMPLE AVAILABLE
No
STUDY DESCRIPTION
Background: Some above ground nuclear tests conducted from 1949 to 1962 at the Semipalatinsk Nuclear Test Site led to radiation exposure of the public. In the frame of the Hiroshima-Semipalatinsk Project (an NGO activity; Kawano et al., 2003) medical examinations for hypothyroidism, thyroid cancer, and thyroid nodules were conducted. The purpose was to provide documentation that might be used in determining whether these exposures had an impact on public health.
Methods: The study design was a series of cross-sectional studies. Interviews were conducted and questionnaires administered to ascertain information on date of birth, height, weight, family structure, exposure status of family members, place of residence at the time of exposure, the number of deliveries for females, etc. In a second step, urine samples were taken for determining stable iodine concentrations, blood samples were taken to determine the thyroid hormone status, palpations were done to investigate the physical status of the thyroid gland, and finally ultrasound examinations were conducted to better determine the presence and size of physical abnormalities. When indicated, nodule punctures were taken.
Results: 1,287 examinations were carried out among 1,067 study participants. 456 were believed to have been exposed and 577 were not. For 34 participants, the exposure situation could not be determined.
Analyses: To date, risks for hypothyroidism, for thyroid cancer, and for thyroid nodules were analysed (Grosche et al., 2017) in relation to exposure status. Still, there is a lot of information not yet analysed, particularly the parameters describing thyroid function, i.e. T3, T4 and TSH, and medication. Another topic is the development of thyroid disorders over time, which can be analysed for those study subjects with more than one examination.
For access to the data contact the uploader at bgrosche [at] t-online.de

STOREDB:DATASET1167 Statistical information [DOI:10.20348/STOREDB/1108/1167]


Created on:2018-08-11 22:17:36 Modified On:2018-08-11 22:17:36
DATASET NAME
Statistical information
DOIDOI:10.20348/STOREDB/1108/1167
DATASET DESCRIPTION
This dataset includes the information on how the original data were prepared for analysis, the codebook, the script for statistical analysis, and the output from this analysis.

STOREDB:DATASET1166 Publications [DOI:10.20348/STOREDB/1108/1166]


Created on:2018-08-11 22:09:34 Modified On:2018-08-11 22:12:00
DATASET NAME
Publications
DOIDOI:10.20348/STOREDB/1108/1166
DATASET DESCRIPTION
The publication on study resulst and a publication about the Hiroshima-Semipalatinsk Project (NGO)