STOREDB:STUDY1138 Radiobiological Archive of Large-scale Animal Experiments at QST-NIRS: J-SHARE [DOI:10.20348/STOREDB/1138]

Study meta-data


STUDYIDSTOREDB:STUDY1138
CREATEDON2019-05-02 15:16:55
MODIFIEDON2019-05-02 15:16:55
UPLOADERPaul Schofield
DOIDOI:10.20348/STOREDB/1138

Study details


STUDY NAME
Radiobiological Archive of Large-scale Animal Experiments at QST-NIRS: J-SHARE
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
CC-Attribution Non-Commercial
COUNTRY
Japan
PRINCIPAL INVESTIGATOR
Yutaka Yamada
SPECIES
Mus musculus
SIZE OF COHORT
10000-99999
OUTCOME
Cancer
EXPOSURE CONTEXT
Medical
INTERNAL OR EXTERNAL EXPOSURE
External
TYPE OF EXTERNAL EXPOSURE
mixed
EXPOSURE PATTERN
Multiple
DOSE RATE
Mixed
BIOLOGICAL SAMPLE AVAILABLE
Yes
ECOLOGICAL DATA
No
STUDY DESCRIPTION
The Japanese Institutes for Quantum and Radiological Science and Technology (QST) and its National Institute of Radiological Sciences have had a program of large-scale external exposure of rodents to a variety of radiation qualities, X ray, γ, neutron and heavy ions using the Heavy Ion Medical Accelerator at Chiba (HIMAC). These experiments focus on cancer research and many of the experiments are lifespan studies, mostly on wild type or genetically manipulated inbred mice and rats. The QST-NIRS has decided to make their accumulated primary data on more than 13, 000 animals available through the J-Share database (Morioka et al., 2019 submitted). This database adds to the very large-scale mouse experiments discussed above with the exception not only containing legacy data but in principle will be augmented by new data from ongoing experiments. J-SHARE also includes an extensive archive of biological specimens. To date these consist of material from:

Lifespan studies of 10,220 B6C3F1 male and female mice at different life stages, irradiated with gamma rays, carbon ions and neutrons.
Studies on mammary gland and lung carcinogenesis with 2,200 Sprague Dawley female rats and 1,429 Wistar female rats, respectively.
Studies on brain, digestive tract and renal tumorigenesis utilizing genetically-modified animals.
Studies on the combined effect of radiation and chemicals.
Studies for anticarcinogenic properties of caloric restriction and specific antioxidant nutrients and phytochemicals.

Frozen samples are retained along with experimental protocols, paraffin blocks, and histopathological slides. Digitisation of slides is being carried out to produce an archive of zoomable images using the Hamamatsu NanoZoomer. Embedded and frozen tissues are available for molecular analysis.
https://www.nirs.qst.go.jp/ENG/core/ref/index.html