STOREDB:STUDY1139 Institute of Environmental Studies database [DOI:10.20348/STOREDB/1139]

Study meta-data


STUDYIDSTOREDB:STUDY1139
CREATEDON2019-05-02 15:26:33
MODIFIEDON2019-05-02 15:26:33
UPLOADERPaul Schofield
DOIDOI:10.20348/STOREDB/1139

Study details


STUDY NAME
Institute of Environmental Studies database
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
Other (specify in 'description')
COUNTRY
Japan
PRINCIPAL INVESTIGATOR
Ignatia Braga-Tanaka
SPECIES
Mus musculus
SIZE OF COHORT
10000-99999
OUTCOME
Cancer
MELODI RESEARCH PRIORITY
Analysis of mechanisms involved in low dose radiation through use and development of suitable cellular and animal models
INTERNAL OR EXTERNAL EXPOSURE
External
TYPE OF EXTERNAL EXPOSURE
gamma
EXPOSURE PATTERN
Protracted
DOSE RATE
Low
BIOLOGICAL SAMPLE AVAILABLE
Yes
ECOLOGICAL DATA
No
STUDY DESCRIPTION
For the past 22 years the Institute of Environmental studies (IES) in Rokkasho, Aomori prefecture, Japan has been studying the biological effects of long-term external exposure in mice (Braga-Tanaka et al. 2018). The facility at the IES is important in its ability to deliver low doses over the complete lifetime of an experimental animal. Dose rates of 0.05-1 mGy over 400 days, comparable to the doses accumulated by radiation workers. Mice subsequently analysed for lifespan compromise, cancer and other disease plus chromosome abnormalities and transgenerational effects. The accumulated datasets and biological specimens represent a major resource for chronic dose effect assessment and have an important input into the determination of safety limits and risk, especially for occupational exposure.
PUBMED ID
29533133