STOREDB:STUDY1159 Exposure to low dose ionizing radiation and titanium dioxide nanoparticles provokes acute arrhythmia and molecular changes indicative of heart failure [DOI:10.20348/STOREDB/1159]

Study meta-data


STUDYIDSTOREDB:STUDY1159
CREATEDON2020-04-16 16:15:45
MODIFIEDON2020-04-16 16:15:45
UPLOADEROmid Azimzadeh
DOIDOI:10.20348/STOREDB/1159

Study details


STUDY NAME
Exposure to low dose ionizing radiation and titanium dioxide nanoparticles provokes acute arrhythmia and molecular changes indicative of heart failure
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
CC-Attribution Non-Commercial
COUNTRY
Germany
PRINCIPAL INVESTIGATOR
Prof.Atkinson
SIZE OF COHORT
0-999
OUTCOME
Cardiovascular
MELODI RESEARCH PRIORITY
Examination of the mechanisms and effects of mixed and multi-exposure on cells, tissues, animal models and humans.
EXPOSURE CONTEXT
Environmental
INTERNAL OR EXTERNAL EXPOSURE
External
TYPE OF EXTERNAL EXPOSURE
X-ray
AGE AT EXPOSURE
Adult
EXPOSURE PATTERN
Acute
DOSE RATE
High
BIOLOGICAL SAMPLE AVAILABLE
Yes
ECOLOGICAL DATA
No
STUDY DESCRIPTION
Given that exposure to radiation and to nanoparticles individually produce detrimental changes to the heart, it is important to establish if there are more serious detrimental consequences arising from an exposure to both agents. We have adopted an experimental approach using ex-vivo guinea pig hearts perfused with a miniaturized Langendorff-device to determine if there are acute changes in heart function or biology arising from an acute exposure to ionizing radiation followed immediately by exposure to nanoparticles. This study indicates the combined noxae evoke a unique of adverse effects and provide mechanistic evidence to understand the interaction.
MEAN DURATION OF FOLLOW-UP (WEEKS)
1